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|Title: ||The stereochemical outcome of allyl magnesium and indium additions to 5-substituted norbornen-7-ones and its application to cis fused carbocycle formation via ring rearrangement metathesis|
|Authors: ||Standen, Patricia E.|
Elsegood, Mark R.J.
Teat, Simon J.
Kimber, Marc C.
|Issue Date: ||2012|
|Publisher: ||© The Royal Society of Chemistry|
|Citation: ||STANDEN, P.E. ... et al, 2012. The stereochemical outcome of allyl magnesium and indium additions to 5-substituted norbornen-7-ones and its application to cis fused carbocycle formation via ring rearrangement metathesis. Organic and Biomolecular Chemistry, 10 (43), pp. 8669 - 8676|
|Abstract: ||The addition of allyl magnesium and allyl indium reagents to a key TBS protected norbornenyl building block, synthesised in 6-steps from commercially available 1,1-dimethoxy-2,3,4,5-tetrachlorocyclopentadiene, has been achieved providing the syn addition products with high diastereoselectivity. The subsequent exposure of the addition products to metathesis conditions, in the presence of ethene, then provided cis fused[3.0.3]-carbocycles with very high regioselectivity, via a Ring Rearrangement Metathesis (RRM) transformation.|
|Description: ||This article is closed access, it was published in the journal Organic and Biomolecular Chemistry [© The Royal Society of Chemistry]. The definitive version is available at: http://dx.doi.org/10.1039/c2ob26784e|
|Publisher Link: ||http://dx.doi.org/10.1039/c2ob26784e|
|Appears in Collections:||Closed Access (Chemistry)|
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