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Title: Total synthesis of the marine-derived cyclic depsipeptide alternaramide
Authors: Horton, Alexandra E.
May, Oliver S.
Elsegood, Mark R.J.
Kimber, Marc C.
Keywords: Natural product
Depsipeptide
Peptide coupling
Macrolactonization
Macrolactamization
Issue Date: 2011
Publisher: © Georg Thieme Verlag
Citation: HORTON, A.E. ... et al, 2011. Total synthesis of the marine-derived cyclic depsipeptide alternaramide. Synlett, 22 (6), pp. 797 - 800
Abstract: The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.
Description: This article was published in the journal, Synlett [© Georg Thieme Verlag]. The definitive version is available at: http://dx.doi.org/10.1055/s-0030-1259915
Version: Accepted for publication
DOI: 10.1055/s-0030-1259915
URI: https://dspace.lboro.ac.uk/2134/13937
Publisher Link: http://dx.doi.org/10.1055/s-0030-1259915
ISSN: 0936-5214
Appears in Collections:Published Articles (Chemistry)

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