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Title: | Total synthesis of the marine-derived cyclic depsipeptide alternaramide |
Authors: | Horton, Alexandra E. May, Oliver S. Elsegood, Mark R.J. Kimber, Marc C. |
Keywords: | Natural product Depsipeptide Peptide coupling Macrolactonization Macrolactamization |
Issue Date: | 2011 |
Publisher: | © Georg Thieme Verlag |
Citation: | HORTON, A.E. ... et al, 2011. Total synthesis of the marine-derived cyclic depsipeptide alternaramide. Synlett, 22 (6), pp. 797 - 800 |
Abstract: | The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds. |
Description: | This article was published in the journal, Synlett [© Georg Thieme Verlag]. The definitive version is available at: http://dx.doi.org/10.1055/s-0030-1259915 |
Version: | Accepted for publication |
DOI: | 10.1055/s-0030-1259915 |
URI: | https://dspace.lboro.ac.uk/2134/13937 |
Publisher Link: | http://dx.doi.org/10.1055/s-0030-1259915 |
ISSN: | 0936-5214 |
Appears in Collections: | Published Articles (Chemistry)
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