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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/14056

Title: Design and validation of a physiologically-adapted bioreactor for tissue engineering of the nucleus pulposus
Authors: Win Naing, May
Liu, Yang
Sebastine, Immanuel
Dingmann, David
Williams, Chrysanthi
Williams, David J.
Keywords: Bioreactor
Tissue engineering
Nucleus pulposus
Mechanical stimulation
Issue Date: 2013
Publisher: © 2013 by the authors; licensee MDPI, Basel, Switzerland
Citation: WIN NAING, M. ... et al., 2013. Design and validation of a physiologically-adapted bioreactor for tissue engineering of the nucleus pulposus. Processes, 2 (1), pp. 1-11.
Abstract: A novel multi-axial bioreactor was designed and developed to deliver combinations of the following dynamic mechanical stimulation conditions: hydrostatic pressure, pulsatile perfusion flow and uniaxial compression in order to mimic in vivo conditions. This mechanical arrangement simultaneously allows triaxial stimulation and characterization of mechanical properties of samples, in particular simulating the conditions experienced by the nucleus pulposus in vivo. A series of initial experiments were performed on this prototype system using consistent, commercially-available, three dimensional scaffolds in combination with human dermal fibroblasts. Our results show that while such bioreactors hold much promise in tissue engineering of desired organs, achieving the right combination of mechanical stimuli and other conditions required in order to enhance the final properties of the cell-scaffold systems is challenging.
Description: This is an Open Access Article. It is published by MDPI, Basel, Switzerland under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/
Sponsor: This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) [grant number EP/C534247/1].
Version: Published
DOI: 10.3390/pr2010001
URI: https://dspace.lboro.ac.uk/2134/14056
Publisher Link: http://dx.doi.org/10.3390/pr2010001
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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