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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/14129

Title: In vitro and in vivo characterisation of buprenorphine and other long-lasting opioids
Authors: Neilan, Claire L.
Issue Date: 1999
Publisher: © Claire L. Neilan
Abstract: Buprenorphine is a promising medication for the treatment of opiate abuse. The pharmacology of buprenorphine has been studied in vitro using radioligand binding and [-35S]GTPyS assays, and in vivo using assays of antinociception in rodents. A number of compounds with potential similar pharmacology have also been characterised. These are an iso-morphinan pyrrolidine derivative, and long-lasting 14-aminomorphinones and codeinones, in particular clocinnamox (C-CAM), a pure μ-antagonist and methoclocinnamox (MC-CAM), which has some agonist properties.... cont'd.
Description: A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.
URI: https://dspace.lboro.ac.uk/2134/14129
Appears in Collections:PhD Theses (Chemistry)

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