Buprenorphine is a promising medication for the treatment of opiate abuse. The
pharmacology of buprenorphine has been studied in vitro using radioligand binding
and [-35S]GTPyS assays, and in vivo using assays of antinociception in rodents. A
number of compounds with potential similar pharmacology have also been
characterised. These are an iso-morphinan pyrrolidine derivative, and long-lasting
14-aminomorphinones and codeinones, in particular clocinnamox (C-CAM), a pure μ-antagonist
and methoclocinnamox (MC-CAM), which has some agonist properties.... cont'd.
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.