Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/14175

Title: Reduced thymic output in elite athletes
Authors: Prieto-Hinojosa, Adria
Knight, Andrea
Compton, Claude
Gleeson, Michael
Travers, Paul J.
Keywords: Exercise immunology
Naive T cell
Issue Date: 2014
Publisher: © Elsevier
Citation: PRIETO-HINOJOSA, A. ... et al, 2014. Reduced thymic output in elite athletes. Brain, Behavior, and Immunity, 39, pp.75-79.
Abstract: Athletes undergoing intensive training schedules have chronic exposure to stress-induced hormones such as cortisol that can depress immune function. We compared the circulating levels of T cell receptor excision circles (TREC), a marker of recent thymic emigrants, as well as the levels of naïve and memory subsets in a group of elite endurance athletes and in controls. The athletes showed a reduction in absolute numbers of naïve T cells, particularly in CD4 T cells. In contrast, memory cells were increased. TREC levels in the athletes were significantly reduced compared to age-matched controls. Such changes resemble premature ageing of the T cell component of the immune system. Since thymic production of T cells naturally decline with age, these results raise the concern that prolonging high intensity exercise into the 4th decade of life may have deleterious consequences for athletes' health. © 2014 Elsevier Inc. All rights reserved.
Description: This article was published in the journal, Brain, Behavior, and Immunity [© Elsevier]. The definitive version is available at: http://dx.doi.org/10.1016/j.bbi.2014.01.004
Version: Accepted for publication
DOI: 10.1016/j.bbi.2014.01.004
URI: https://dspace.lboro.ac.uk/2134/14175
Publisher Link: http://dx.doi.org/10.1016/j.bbi.2014.01.004
ISSN: 0889-1591
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

Files associated with this item:

File Description SizeFormat
Prieto-Hinojosa et al 2014 ACCEPTED BBI MANUSCRIPT.pdfAccepted version7.15 MBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.