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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/14259

Title: Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications
Authors: Robinson, Nathalie J.
Picken, Andrew
Coopman, Karen
Keywords: Cell pausing
Cell therapy
Cold-induced stress
Cryopreservation
Hypothermic preservation
HypoThermosol-FRS
Stem cells
Issue Date: 2014
Publisher: © Springer
Citation: ROBINSON, N.J., PICKEN, A. and COOPMAN, K., 2014. Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications. Biotechnology Letters, 36 (2), pp. 201 - 209.
Abstract: Encouraging advances in cell therapies have produced a requirement for an effective short-term cell preservation method, enabling time for quality assurance testing and transport to their clinical destination. Low temperature pausing of cells offers many advantages over cryopreservation, including the ability to store cells at scale, reduced cost and a simplified procedure with increased reliability. This review will focus on the importance of developing a short-term cell preservation platform as well highlighting the major successes of cell pausing and the key challenges which need addressing, to enable application of the process to therapeutically relevant cells.
Description: This article was published in the journal, Biotechnology Letters [© Springer] and the definitive version is available at: http://dx.doi.org/10.1007/s10529-013-1349-5
Version: Accepted for publication
DOI: 10.1007/s10529-013-1349-5
URI: https://dspace.lboro.ac.uk/2134/14259
Publisher Link: http://dx.doi.org/10.1007/s10529-013-1349-5
ISSN: 0141-5492
Appears in Collections:Published Articles (Chemical Engineering)

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