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Title: Influence of hydration status on changes in plasma cortisol, leukocytes and antigen-stimulated cytokine production by whole blood culture following prolonged exercise.
Authors: Svendsen, Ida S.
Killer, Sophie C.
Gleeson, Michael
Issue Date: 2014
Publisher: Hindawi Publishing Corporation / © The authors
Citation: SVENDSEN, I.S., KILLER, S.C. and GLEESON, M., 2014. Influence of hydration status on changes in plasma cortisol, leukocytes and antigen-stimulated cytokine production by whole blood culture following prolonged exercise. ISRN Nutrition, 2014, Article ID 561401
Abstract: Elevated antigen-stimulated anti-inflammatory cytokine production appears to be a risk factor for upper respiratory tract illness in athletes. The purpose of this study was to determine the effects of prolonged exercise and hydration on antigen-stimulated cytokine production. Twelve healthy males cycled for 120min at 60% 𝑉O2 max on two occasions, either euhydrated or moderately hypohydrated (induced by fluid restriction for 24 h). Blood samples were collected before and after exercise and following 2 h recovery for determination of cell counts, plasma cortisol, and in vitro antigen-stimulated cytokine production by whole blood culture. Fluid restriction resulted in mean body mass loss of 1.3% and 3.9% before and after exercise, respectively. Exercise elicited a significant leukocytosis and elevated plasma cortisol, with no differences between trials. IL-6 production was significantly reduced 2 h postexercise (𝑃 < 0.05), while IL-10 production was elevated postexercise (𝑃 < 0.05). IFN-𝛾 and IL-2 production tended to decrease postexercise. No significant effect of hydration status was observed for the measured variables. Prolonged exercise appears to result in augmented anti-inflammatory cytokine release in response to antigen challenge, possibly coupled with acute suppression of proinflammatory cytokine production, corresponding with studies using mitogen or endotoxin as stimulant. Moderate hypohydration does not appear to influence these changes.
Description: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Version: Published
DOI: 10.1155/2014/561401
URI: https://dspace.lboro.ac.uk/2134/14324
Publisher Link: http://dx.doi.org/10.1155/2014/561401
ISSN: 2314-4068
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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