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Title: Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine
Authors: Nayak, Atul
Das, Diganta Bhusan
Keywords: Biodegradable
Drug delivery
Tensile strength
Issue Date: 2013
Publisher: © Springer Science+Business Media
Citation: NAYAK, A. and DAS, D.B., 2013. Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine. Biotechnology Letters, 35 (9), pp. 1351 - 1363.
Abstract: There has been an increasing interest in applying biotechnology in formulating and characterising new and innovative drug delivery methods, e.g., drug-loaded biodegradable microneedles within the area of transdermal delivery technology. Recently, microneedles have been proposed for use in pain management, e.g., post-operative pain management through delivery of a local anaesthetic, namely, lidocaine. Lidocaine is a fairly common, marketed prescription-based, local anaesthetic pharmaceutical, applied for relieving localised pain and lidocaineloaded microneedles have been explored. The purpose of this review is to evaluate the properties of biodegradable polymers that may allow the preparation of microneedle systems, methods of preparing them and pharmacokinetic conditions in considering the potential use of lidocaine for delivery through the skin.
Description: This article was published in the journal Biotechnology Letters [© Springer Science+Business Media]. The definitive version is available at: http://dx.doi.org/10.1007/s10529-013-1217-3
Version: Accepted for publication
DOI: 10.1007/s10529-013-1217-3
URI: https://dspace.lboro.ac.uk/2134/14346
Publisher Link: http://dx.doi.org/10.1007/s10529-013-1217-3
ISSN: 0141-5492
Appears in Collections:Published Articles (Chemical Engineering)

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