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Title: Potential of microneedle-assisted micro-particle delivery by gene guns: a review
Authors: Zhang, Dongwei
Das, Diganta Bhusan
Rielly, Chris D.
Keywords: Gene gun
Penetration depth
Issue Date: 2014
Publisher: © Informa Healthcare USA, Inc.
Citation: ZHANG, D., DAS, D.B. and RIELLY, C.D., 2014. Potential of microneedle-assisted micro-particle delivery by gene guns: a review. Drug Delivery, 21(8), pp. 571-587.
Abstract: Abstact Context: Gene guns have been used to deliver deoxyribonucleic acid (DNA) loaded micro-particle and breach the muscle tissue to target cells of interest to achieve gene transfection. Objective: This article aims to discuss the potential of microneedle (MN) assisted micro-particle delivery from gene guns, with a view to reducing tissue damage. Methods: Using a range of sources, the main gene guns for micro-particle delivery are reviewed along with the primary features of their technology, e.g. their design configurations, the material selection of the micro-particle, the driving gas type and pressure. Depending on the gene gun system, the achieved penetration depths in the skin are discussed as a function of the gas pressure, the type of the gene gun system and particle size, velocity and density. The concept of MN-assisted micro-particles delivery which consists of three stages (namely, acceleration, separation and decoration stage) is discussed. In this method, solid MNs are inserted into the skin to penetrate the epidermis/dermis layer and create holes for particle injection. Several designs of MN array are discussed and the insertion mechanism is explored, as it determines the feasibility of the MN-based system for particle transfer. Results: This review suggests that one of the problems of gene guns is that they need high operating pressures, which may result in direct or indirect tissue/cells damage. MNs seem to be a promising method which if combined with the gene guns may reduce the operating pressures for these devices and reduce tissue/cell damages. Conclusions: There is sufficient potential for MN-assisted particle develivery systems.
Description: This article was published in the journal Drug Delivery [© Informa Healthcare USA, Inc]. The definitive version is available at: http://dx.doi.org/10.3109/10717544.2013.864345
Version: Accepted for publication
DOI: 10.3109/10717544.2013.864345
URI: https://dspace.lboro.ac.uk/2134/14349
Publisher Link: http://dx.doi.org/10.3109/10717544.2013.864345
ISSN: 1071-7544
Appears in Collections:Published Articles (Chemical Engineering)

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