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|Title: ||Brachial artery modifications to blood flow-restricted handgrip training and detraining|
|Authors: ||Hunt, Julie E.A.|
Walton, Lucy A.
Ferguson, Richard A.
|Issue Date: ||2012|
|Publisher: ||© American Physiological Society|
|Citation: ||HUNT, J.E.A., WALTON, L.A. and FERGUSON, R.A., 2012. Brachial artery modifications to blood flow-restricted handgrip training and detraining. Journal of Applied Physiology, 112 (6), pp. 956 - 961|
|Abstract: ||Low load resistance training with blood flow restriction (BFR) can increase muscle size and strength, but the implications on the conduit artery are uncertain. We examined the effects of low-load dynamic handgrip training with and without BFR, and detraining, on measures of brachial artery function and structure. Nine male participants (26 ± 4 yr, 178 ± 3 cm, 78 ± 10 kg) completed 4 wk (3 days/wk) of dynamic handgrip training at 40% 1 repetition maximum (1RM). In a counterbalanced manner, one forearm trained under BFR (occlusion cuff at 80 mmHg) and the other under nonrestricted (CON) conditions. Brachial artery function [flow-mediated dilation (FMD)] and structure (diameter) were assessed using Doppler ultrasound. Measurements were made before training (pretraining), after training (posttraining), and after 2-wk no training (detraining). Brachial artery diameter at rest, in response to 5-min ischemia (peak diameter), and ischemic exercise (maximal diameter) increased by 3.0%, 2.4%, and 3.1%, respectively, after BFR training but not after CON. FMD did not change at any time point in either arm. Vascular measures in the BFR arm returned to baseline after 2 wk detraining with no change after CON. The data demonstrate that dynamic low-load handgrip training with BFR induced transient adaptations to conduit artery structure but not function. Copyright © 2012 the American Physiological Society.|
|Description: ||This article is closed access.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1152/japplphysiol.00905.2011|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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