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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/14993

Title: Precision manufacturing for clinical-quality regenerative medicines
Authors: Williams, David J.
Thomas, Robert James
Hourd, Paul C.
Chandra, Amit
Ratcliffe, Elizabeth
Liu, Yang
Rayment, Erin
Archer, J. Richard
Keywords: Regenerative medicine
Stem cells
Issue Date: 2012
Publisher: © The Royal Society
Citation: WILLIAMS, D.J. ... et al, 2012. Precision manufacturing for clinical-quality regenerative medicines. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 370 (1973), pp. 3924 - 3949.
Abstract: Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice—extreme levels of repeatability and reliability—demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.
Description: This article was published in the journal, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences [© The Royal Society]. The definitive version is available at: http://dx.doi.org/10.1098/rsta.2011.0049
Version: Submitted for publication
DOI: 10.1098/rsta.2011.0049
URI: https://dspace.lboro.ac.uk/2134/14993
Publisher Link: http://dx.doi.org/10.1098/rsta.2011.0049
ISSN: 1364-503X
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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