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Title: Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom
Authors: Ghelani, Anant M.
Samanta, Ash
Jones, Adrian C.
Mastana, Sarabjit S.
Keywords: RA
South Asian
Caucasian
TNFR2
VDR
A2M
GSTs
ACE
Issue Date: 2011
Publisher: © Springer-Verlag
Citation: GHELANI, A.M. ... et al, 2011. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatology International, 31 (10), pp. 1355 - 1361
Abstract: Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT , GSTM and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST Tnull (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST Tnull genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA. © 2010 Springer-Verlag.
Description: This article is closed access.
Version: Published
DOI: 10.1007/s00296-010-1478-2
URI: https://dspace.lboro.ac.uk/2134/15061
Publisher Link: http://dx.doi.org/10.1007/s00296-010-1478-2
ISSN: 0172-8172
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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