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|Title: ||Hormone replacement therapy to maintain cognitive function in women with dementia|
|Authors: ||Hogervorst, Eef|
Huppert, Felicia A.H.
|Issue Date: ||2009|
|Publisher: ||John Wiley and Sons / © 2009 The Cochrane Collaboration|
|Citation: ||HOGERVORST, E. ... et al, 2009. Hormone replacement therapy to maintain cognitive function in women with dementia. Cochrane Database of Systematic Reviews, 1, CD003799.|
As estrogens have been shown to have several potentially beneficial effects on the central nervous system, it is biologically plausible that
maintaining high levels of estrogens in postmenopausal women by means of estrogen replacement therapy (ERT) could be protective
against cognitive decline in women with Alzheimer’s disease (AD) or other dementia syndromes.
To investigate the effects of ERT (estrogens only) or HRT (estrogens combined with a progestagen) compared with placebo in
randomized controlled trials (RCTs) on cognitive function of postmenopausal women with dementia.
TheCochraneDementia andCognitive ImprovementGroup SpecializedRegister,which contains records frommanymedical databases,
The Cochrane Library, EMBASE,MEDLINE, CINAHL, PsycINFO and LILACS were searched on 7 November 2007 using the terms
ORT, PORT, ERT, HRT, estrogen*, oestrogen* and progesterone*.
All double-blind randomized controlled trials (RCTs) into the effect of ERT or HRT for cognitive function with a treatment period of
at least two weeks in postmenopausal women with AD or other types of dementia.
Data collection and analysis
Abstracts of the references retrieved by the searches were read by two reviewers (EH and KY) independently in order to discard those
that were clearly not eligible for inclusion. The two reviewers studied the full text of the remaining references and independently selected
studies for inclusion. Any disparity in the ensuing lists was resolved by discussion with all reviewers in order to arrive at the final list
of included studies. The selection criteria ensured that the blinding and randomization of the included studies was adequate. The two
reviewers also assessed the quality of other aspects of the included trials. One reviewer (EH) extracted the data from the studies, but
was aided and checked by JB from Cochrane.|
|Description: ||This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2009, Issue 1. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.|
|Publisher Link: ||http://dx.doi.org/10.1002/14651858.CD003799.pub2|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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