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|Title: ||Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults|
|Authors: ||Leishear, Kira|
Boudreau, Robert M.
Studenski, Stephanie A.
de Rekeneire, Nathalie
Houston, Denise K.
Kritchevsky, Stephen B.
Schwartz, Ann V.
Vinik, Aaron I.
Harris, Tamara B.
Newman, Anne B.
Strotmeyer, Elsa S.
|Keywords: ||Low B12|
Sensory peripheral nerve function
Motor nerve conduction
|Issue Date: ||2012|
|Publisher: ||Wiley / © The Authors. Journal compilation © The American Geriatrics Society|
|Citation: ||LEISHEAR, K. ... et al, 2012. Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults. Journal of the American Geriatrics Society, 60 (6), pp. 1057 - 1063.|
|Abstract: ||OBJECTIVES: To examine whether deficient B12 status
or low serum B12 levels are associated with worse sensory
and motor peripheral nerve function in older adults.
SETTING: Health, Aging and Body Composition Study.
PARTICIPANTS: Two thousand two hundred and eightyseven
adults aged 72 to 83 (mean 76.5 ± 2.9; 51.4%
female; 38.3% black).
MEASUREMENTS: Low serum B12 was defined as
serum B12 less than 260 pmol/L, and deficient B12 status
was defined as B12 less than 260 pmol/L, methylmalonic
acid (MMA) greater than 271 nmol/L, and MMA greater
than 2-methylcitrate. Peripheral nerve function was
assessed according to peroneal nerve conduction amplitude
and velocity (NCV) (motor), 1.4 g/10 g monofilament
detection, average vibration threshold detection, and
peripheral neuropathy symptoms (numbness, aching or
burning pain, or both) (sensory). RESULTS: B12-deficient status was found in 7.0% of participants,
and an additional 10.1% had low serum B12
levels. B12 deficient status was associated with greater
insensitivity to light (1.4 g) touch (odds ratio = 1.50, 95%
confidence interval = 1.06–2.13) and worse NCV (42.3 vs
43.5 m/s) (b = 1.16, P = .01) after multivariable adjustment
for demographics, lifestyle factors, and health conditions.
Associations were consistent for the alternative
definition using low serum B12 only. No significant associations
were found for deficient B12 status or the alternative
low serum B12 definition and vibration detection,
nerve conduction amplitude, or peripheral neuropathy
CONCLUSION: Poor B12 (deficient B12 status and low
serum B12) is associated with worse sensory and motor
peripheral nerve function. Nerve function impairments
may lead to physical function declines and disability in
older adults, suggesting that prevention and treatment of
low B12 levels may be important to evaluate.|
|Description: ||This article is closed access.|
|Publisher Link: ||http://dx.doi.org/10.1111/j.1532-5415.2012.03998.x|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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