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Title: Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults
Authors: Leishear, Kira
Boudreau, Robert M.
Studenski, Stephanie A.
Ferrucci, Luigi
Rosano, Caterina
de Rekeneire, Nathalie
Houston, Denise K.
Kritchevsky, Stephen B.
Schwartz, Ann V.
Vinik, Aaron I.
Hogervorst, Eef
Yaffe, Kristine
Harris, Tamara B.
Newman, Anne B.
Strotmeyer, Elsa S.
Keywords: Low B12
Deficient B12
Sensory peripheral nerve function
Motor nerve conduction
Older adults
Issue Date: 2012
Publisher: Wiley / © The Authors. Journal compilation © The American Geriatrics Society
Citation: LEISHEAR, K. ... et al, 2012. Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults. Journal of the American Geriatrics Society, 60 (6), pp. 1057 - 1063.
Abstract: OBJECTIVES: To examine whether deficient B12 status or low serum B12 levels are associated with worse sensory and motor peripheral nerve function in older adults. DESIGN: Cross-sectional. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Two thousand two hundred and eightyseven adults aged 72 to 83 (mean 76.5 ± 2.9; 51.4% female; 38.3% black). MEASUREMENTS: Low serum B12 was defined as serum B12 less than 260 pmol/L, and deficient B12 status was defined as B12 less than 260 pmol/L, methylmalonic acid (MMA) greater than 271 nmol/L, and MMA greater than 2-methylcitrate. Peripheral nerve function was assessed according to peroneal nerve conduction amplitude and velocity (NCV) (motor), 1.4 g/10 g monofilament detection, average vibration threshold detection, and peripheral neuropathy symptoms (numbness, aching or burning pain, or both) (sensory). RESULTS: B12-deficient status was found in 7.0% of participants, and an additional 10.1% had low serum B12 levels. B12 deficient status was associated with greater insensitivity to light (1.4 g) touch (odds ratio = 1.50, 95% confidence interval = 1.06–2.13) and worse NCV (42.3 vs 43.5 m/s) (b = 1.16, P = .01) after multivariable adjustment for demographics, lifestyle factors, and health conditions. Associations were consistent for the alternative definition using low serum B12 only. No significant associations were found for deficient B12 status or the alternative low serum B12 definition and vibration detection, nerve conduction amplitude, or peripheral neuropathy symptoms. CONCLUSION: Poor B12 (deficient B12 status and low serum B12) is associated with worse sensory and motor peripheral nerve function. Nerve function impairments may lead to physical function declines and disability in older adults, suggesting that prevention and treatment of low B12 levels may be important to evaluate.
Description: This article is closed access.
Version: Published
DOI: 10.1111/j.1532-5415.2012.03998.x
URI: https://dspace.lboro.ac.uk/2134/15098
Publisher Link: http://dx.doi.org/10.1111/j.1532-5415.2012.03998.x
ISSN: 0002-8614
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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