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|Title: ||Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men|
|Authors: ||West, Daniel W.D.|
Kujbida, Gregory W.
Moore, Daniel R.
Atherton, Philip J.
Burd, Nicholas A.
Padzik, Jan P.
De Lisio, Michael
Tang, Jason E.
Rennie, Michael J.
Baker, Steven K.
Phillips, Stuart M.
|Issue Date: ||2009|
|Publisher: ||Wiley / © The Authors. Journal compilation © The Physiological Society|
|Citation: ||WEST, D.W.D. ... et al, 2009. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. Journal of Physiology, 587 (21), pp. 5239 - 5247|
|Abstract: ||We aimed to determine whether exercise-induced elevations in systemic concentration of testosterone, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) enhanced post-exercise myofibrillar protein synthesis (MPS) and phosphorylation of signalling proteins important in regulating mRNA translation. Eight young men (20 ± 1.1 years, BMI = 26 ± 3.5 kg m) completed two exercise protocols designed to maintain basal hormone concentrations (low hormone, LH) or elicit increases in endogenous hormones (high hormone, HH). In the LH protocol, participants performed a bout of unilateral resistance exercise with the elbow flexors. The HH protocol consisted of the same elbow flexor exercise with the contralateral arm followed immediately by high-volume leg resistance exercise. Participants consumed 25 g of protein after arm exercise to maximize MPS. Muscle biopsies and blood samples were taken as appropriate. There were no changes in serum testosterone, GH or IGF-1 after the LH protocol, whereas there were marked elevations after HH (testosterone, P < 0.001; GH, P < 0.001; IGF-1, P < 0.05). Exercise stimulated a rise in MPS in the biceps brachii (rest = 0.040 ± 0.007, LH = 0.071 ± 0.008, HH = 0.064 ± 0.014% h; P < 0.05) with no effect of elevated hormones (P = 0.72). Phosphorylation of the 70 kDa S6 protein kinase (p70S6K) also increased post-exercise (P < 0.05) with no differences between conditions. We conclude that the transient increases in endogenous purportedly anabolic hormones do not enhance fed-state anabolic signalling or MPS following resistance exercise. Local mechanisms are likely to be of predominant importance for the post-exercise increase in MPS. © 2009 The Authors. Journal compilation © 2009 The Physiological Society.|
|Description: ||This article is closed access.|
|Publisher Link: ||http://dx.doi.org/10.1113/jphysiol.2009.177220|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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