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Title: Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men
Authors: Gray, Stuart R.
Robinson, M.
Nimmo, Myra A.
Keywords: Exercise stress
Issue Date: 2008
Publisher: Springer © Cell Stress Society International
Citation: GRAY, S.R., ROBINSON, M. and NIMMO, M.A., 2008. Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress and Chaperones, 13 (2), pp. 247 - 251.
Abstract: The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL- 6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96±6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P<0.01) by 8.4±8.9 pg ml−1 (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P<0.05) by 2.7±3.9 ng ml−1 (9.6%) and 37.7±55.6 ng ml−1 (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
Description: Closed access.
Version: Published
DOI: 10.1007/s12192-008-0019-3
URI: https://dspace.lboro.ac.uk/2134/15159
Publisher Link: http://dx.doi.org/10.1007/s12192-008-0019-3
ISSN: 1355-8145
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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