Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/15283

Title: Averaging level control to reduce off-spec material in a continuous pharmaceutical pilot plant
Authors: Lakerveld, Richard
Benyahia, Brahim
Heider, Patrick L.
Zhang, Haitao
Braatz, Richard D.
Barton, Paul I.
Keywords: Control
Process modeling
Process simulation
Parameter estimation
Dynamic modeling
Optimization
Crystallization
Continuous pharmaceutical manufacturing
Issue Date: 2013
Publisher: MDPI AG, Basel, Switzerland (© the authors)
Citation: LAKERVELD, R. ... et al, 2013. Averaging level control to reduce off-spec material in a continuous pharmaceutical pilot plant. Processes, 1 (3), pp.330-348.
Abstract: The judicious use of buffering capacity is important in the development of future continuous pharmaceutical manufacturing processes. The potential benefits are investigated of using optimal-averaging level control for tanks that have buffering capacity for a section of a continuous pharmaceutical pilot plant involving two crystallizers, a combined filtration and washing stage and a buffer tank. A closed-loop dynamic model is utilized to represent the experimental operation, with the relevant model parameters and initial conditions estimated from experimental data that contained a significant disturbance and a change in setpoint of a concentration control loop. The performance of conventional proportional-integral (PI) level controllers is compared with optimal-averaging level controllers. The aim is to reduce the production of off-spec material in a tubular reactor by minimizing the variations in the outlet flow rate of its upstream buffer tank. The results show a distinct difference in behavior, with the optimal-averaging level controllers strongly outperforming the PI controllers. In general, the results stress the importance of dynamic process modeling for the design of future continuous pharmaceutical processes.
Description: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/3.0/).
Version: Published
DOI: 10.3390/pr1030330
URI: https://dspace.lboro.ac.uk/2134/15283
Publisher Link: http://dx.doi.org/10.3390/pr1030330
http://www.mdpi.com/journal/processes
Appears in Collections:Published Articles (Chemical Engineering)

Files associated with this item:

File Description SizeFormat
processes-01-00330.pdfPublished version2.42 MBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.