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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/15287

Title: End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation
Authors: Mascia, Salvatore
Heider, Patrick L.
Zhang, Haitao
Lakerveld, Richard
Benyahia, Brahim
Barton, Paul I.
Braatz, Richard D.
Cooney, Charles L.
Evans, James M.B.
Jamison, Timothy F.
Jensen, Klavs F.
Myerson, Allan S.
Trout, Bernhardt L.
Jamison, Timothy F.
Keywords: Continuous processing
Flow chemistry
Lactones
Protecting groups
Synthetic methods
Issue Date: 2013
Publisher: © WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation: MASCIA, S. ... et al, 2013. End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation. Angewandte Chemie - International Edition, 52 (47), pp.12359-12363.
Abstract: A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
Description: This paper is closed access.
Version: Published
DOI: 10.1002/anie.201305429
URI: https://dspace.lboro.ac.uk/2134/15287
Publisher Link: http://dx.doi.org/10.1002/anie.201305429
ISSN: 1433-7851
Appears in Collections:Closed Access (Chemical Engineering)

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