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Title: Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity
Authors: McCann, Malachy
Curran, Robert
Ben-Shoshan, Marcia
McKee, Vickie
Tahir, Asif A.
Devereux, Michael
Kavanagh, Kevin
Creaven, Bernadette S.
Kellett, Andrew
Issue Date: 2012
Publisher: © The Royal Society of Chemistry
Citation: McCANN, M. ... et al, 2012. Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity. Dalton Transactions, 41(21), pp.6516-6527.
Abstract: [Ag2(9-aca)2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)2.3(CH3CN)0.7](9-aca) (3), [Ag6(imidH)4(9-aca)6(MeOH)2] (4), {[Ag(1-Me-imid)2]2[Ag4(9- aca)6]} (5), {[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) and [Ag(apim)](9-aca)·H2O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4–6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(I) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.
Description: This item is Closed Access.
Sponsor: Financial support from the Irish Research Council for Science, Engineering and Technology (IRCSET) and the John and Pat Hume Scholarship Scheme, NUI Maynooth (R. Curran) are gratefully acknowledged.
Version: Closed access
DOI: 10.1039/c2dt12166b
URI: https://dspace.lboro.ac.uk/2134/15305
Publisher Link: http://dx.doi.org/10.1039/c2dt12166b
ISSN: 1477-9226
Appears in Collections:Closed Access (Chemistry)

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