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|Title: ||A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments|
|Authors: ||Courneya, Kerry S.|
Sellar, Christopher M.
Forbes, Cynthia C.
McNeely, Margaret L.
Peddle-McIntyre, Carolyn J.
Friedenreich, Christine M.
|Issue Date: ||2012|
|Publisher: ||© American Association of Cancer Research (AACR)|
|Citation: ||COURNEYA, K.S. ... et al, 2012. A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments. Cancer Epidemiology Biomarkers and Prevention, 21(6), pp.887–894.|
|Abstract: ||Background: Patients with lymphoma experience sleep problems that may be managed with aerobic
exercise but no previous study has examined this issue.
Methods: We randomized 122 patients with lymphoma to usual care (n ¼ 62) or 12 weeks of supervised
aerobic exercise training (AET; n ¼ 60). Our primary sleep endpoint was global sleep quality assessed by the
Pittsburgh Sleep Quality Index (PSQI). Secondary endpoints were the PSQI component scores. Planned
subgroup analyses were also conducted.
Results: Intention-to-treat analyses indicated that AET resulted in a nonsignificant (P ¼ 0.16) improvement
in global sleep quality compared with usual care [mean group difference¼ 0.64; 95% confidence interval (CI),
1.56 to þ0.27]. In planned subgroup analyses, statistically significant or borderline significant interactions
were identified for type of lymphoma (Pinteraction
¼ 0.006), current treatment status (Pinteraction
¼ 0.036), time
since diagnosis (Pinteraction
¼ 0.010), body mass index (Pinteraction
¼ 0.075), and baseline sleep quality (Pinteraction
¼ 0.041). Specifically, AET improved global sleep quality in patients with lymphoma who had indolent
non–Hodgkin lymphoma (P ¼ 0.001), were receiving chemotherapy (P ¼ 0.013), were <2 years post-diagnosis
(P ¼ 0.005), were obese (P ¼ 0.025), and were poor sleepers at baseline (P ¼ 0.007).
Conclusions: AET did not significantly improve sleep quality in this heterogeneous sample of patients with
lymphoma; however, clinically identifiable subgroups appeared to benefit. Future exercise trials targeting
these responsive subgroups are needed to confirm these findings.
Impact: If replicated in larger and more focused trials, aerobic exercise may be an attractive option to manage
sleep dysfunction in patients with cancer because of its favorable safety profile and other documented health
|Description: ||This item is Closed Access.|
|Sponsor: ||This work was supported by a grant from the Lance Armstrong
Foundation. K.S. Courneya is supported by the Canada Research Chairs
Program. L. Trinh is supported by a Health Studentship from Alberta
Innovates: Health Solutions (AI:HS). C.M. Friedenreich is supported by a
Senior Health Scholar award from AI:HS.|
|Version: ||Closed access|
|Publisher Link: ||http://dx.doi.org/10.1158/1055-9965.EPI-12-0075|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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