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|Title: ||Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients|
|Authors: ||Courneya, Kerry S.|
Sellar, Christopher M.
McNeely, Margaret L.
Peddle-McIntyre, Carolyn J.
Friedenreich, Christine M.
|Issue Date: ||2009|
|Publisher: ||© American Society of Clinical Oncology|
|Citation: ||COURNEYA, K.S. ... et al, 2009. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. Journal of Clinical Oncology, 27(27), pp.4605-4612.|
Lymphoma patients commonly experience declines in physical functioning and quality of life (QoL)
that may be reversed with exercise training.
Patients and Methods
We conducted a randomized controlled trial in Edmonton, Alberta, Canada, between 2005 and
2008 that stratified 122 lymphoma patients by major disease type and current treatment status
and randomly assigned them to usual care (UC; n 62) or 12 weeks of supervised aerobic
exercise training (AET; n 60). Our primary end point was patient-rated physical functioning
assessed by the Trial Outcome Index-Anemia. Secondary end points were overall QoL, psychosocial
functioning, cardiovascular fitness, and body composition.
Follow-up assessment for our primary end point was 96% (117 of 122) at postintervention and
90% (110 of 122) at 6-month follow-up. Median adherence to the supervised exercise program
was 92%. At postintervention, AET was superior to UC for patient-rated physical functioning
(mean group difference, 9.0; 95% CI, 2.0 to 16.0; P .012), overall QoL (P .021), fatigue
(P .013), happiness (P .004), depression (P .005), general health (P .001), cardiovascular
fitness (P .001), and lean body mass (P .008). Change in peak cardiovascular fitness mediated
the change in patient-rated physical functioning. AET did not interfere with chemotherapy
completion rate or treatment response. At 6-month follow-up, AET was still borderline or
significantly superior to UC for overall QoL (P .054), happiness (P .034), and depression
(P .009) without an increased risk of disease recurrence/progression.
AET significantly improved important patient-rated outcomes and objective physical functioning in
lymphoma patients without interfering with medical treatments or response. Exercise training to
improve cardiovascular fitness should be considered in the management of lymphoma patients.|
|Sponsor: ||Supported by the Lance Armstrong
Foundation. Additional support provided
by the Canada Research Chairs
Program (K.S.C.); by Health Studentships
(C.M.S. and C.J.P.), Senior Health
Scholar Award (C.M.F.), and Clinical
Investigator Award (T.R.) from the
Alberta Heritage Foundation for Medical
Research; by Research Team Grant No.
010282 from the National Cancer Institute
of Canada (NCIC); and by the
Canadian Cancer Society (CCS) and the
NCIC/CCS Sociobehavioral Cancer
Research Network (K.S.C. and C.M.F.).|
|Publisher Link: ||http://dx.doi.org/10.1200/JCO.2008.20.0634|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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