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Title: Lactose: a definitive guide to polymorph determination
Authors: Kirk, Joanne H.
Dann, Sandra E.
Blatchford, C.G.
Keywords: Lactose
X-ray diffraction
Raman spectroscopy
Issue Date: 2007
Publisher: © Elsevier
Citation: KIRK, J.H., DANN, S.E. and BLATCHFORD, C.G., 2007. Lactose: a definitive guide to polymorph determination. International Journal of Pharmaceutics, 334(1-2), pp.103-114.
Abstract: Lactose is a well-known molecule capable of forming a number of different polymorphs with varied chemical and physical properties. To date, no definitive guide for distinguishing between polymorphs using simple analytical techniques has been available. The information presented in this article aims to provide a conclusive guide for identifying the polymorphs of lactose and to successfully unravel years of contradictory research. Data have been collected on single phase polymorphs, prepared from an identical source, adopting the use of in situ and ex situ powder X-ray diffraction, CCD-Raman, FT-IR and 13C–1H cross-polarisation magic angle spinning NMR (CP-MASNMR) spectroscopy, in order to provide simple methods to discriminate between the polymorphs.
Description: This item is Closed Access.
Sponsor: The authors wish to acknowledge 3M Health Care for studentship of JHK.
Version: Closed access
DOI: 10.1016/j.ijpharm.2006.10.026
URI: https://dspace.lboro.ac.uk/2134/15457
Publisher Link: http://dx.doi.org/10.1016/j.ijpharm.2006.10.026
ISSN: 0378-5173
Appears in Collections:Closed Access (Chemistry)

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