Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/15475

Title: Palladium-catalyzed stereoselective intramolecular oxidative amidation of alkenes in the synthesis of 1,3- and 1,4-amino alcohols and 1,3-diamines
Authors: Malkov, Andrei V.
Lee, Darren S.
Elsegood, Mark R.J.
Barlog, Maciej
Kocovsky, Pavel
Keywords: Allylic compounds
Amination
Cyclization
Palladium
Homogeneous catalysis
Catalysis
Issue Date: 2014
Publisher: © Wiley-VCH
Citation: MALKOV, A.V. ... et al., 2014. Palladium-catalyzed stereoselective intramolecular oxidative amidation of alkenes in the synthesis of 1,3- and 1,4-amino alcohols and 1,3-diamines. Chemistry : a European Journal, 20 (17), pp. 4901-4905.
Abstract: An efficient and practical Pd-catalyzed intramolecular oxidative allylic amidation provides facile access to derivatives of 1,3- and 1,4-amino alcohols and 1,3-diamines. The method operates under mild reaction conditions (RT) with molecular oxygen (1 atm) as the sole reoxidant of Pd. Excellent diastereoselectivities were attained with substrates bearing a secondary stereogenic center Nitrogen in, hydrogen out: An efficient and practical Pd-catalyzed intramolecular oxidative allylic amidation provides facile access to derivatives of 1,3- and 1,4-amino alcohols and 1,3-diamines (see scheme). The method operates under mild reaction conditions (RT) with molecular oxygen (1 atm) as the sole reoxidant of Pd. Excellent diastereoselectivities were attained with substrates bearing a secondary stereogenic center.
Description: This is the peer reviewed version of the following article: MALKOV, A.V. ... et al., 2014. Palladium-catalyzed stereoselective intramolecular oxidative amidation of alkenes in the synthesis of 1,3- and 1,4-amino alcohols and 1,3-diamines. Chemistry : a European Journal, 20 (17), pp. 4901-4905, which has been published in final form at: http://dx.doi.org/10.1002/chem.201400123.
Version: Accepted for publication
DOI: 10.1002/chem.201400123
URI: https://dspace.lboro.ac.uk/2134/15475
Publisher Link: http://dx.doi.org/10.1002/chem.201400123
ISSN: 0947-6539
Appears in Collections:Closed Access (Chemistry)

Files associated with this item:

File Description SizeFormat
Darren-Maciej_CEJ-2j-bw.pdfAccepted version252.7 kBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.