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|Title: ||Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines|
|Authors: ||Malkov, Andrei V.|
Stewart-Liddon, Angus J.P.
McGeoch, Grant D.
|Issue Date: ||2012|
|Publisher: ||© Royal Society of Chemistry|
|Citation: ||MALKOV, A.V. ... et al., 2012. Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines. Organic and Biomolecular Chemistry, 10 (25), pp. 4864-4877.|
|Abstract: ||A new family of Lewis basic 2-pyridyl oxazolines have been developed, which can act as efficient organocatalysts for the enantioselective reduction of prochiral aromatic ketones and ketimines with trichlorosilane, a readily available and inexpensive reagent. 1-Isoquinolyl oxazoline, derived from mandelic acid, was identified as the most efficient catalyst of the series, capable of delivering high enantioselectivities in the reduction of both ketones (up to 94% ee) and ketimines (up to 89% ee).|
|Sponsor: ||We thank the EPSRC for grant No. GR/S87294/01, GSK and EPSRC for an
industrial CASE awards to A. J. P. S. L., the Ministry of Education and Science of Spain for a
fellowship to PR-L, the Loughborough University, the University of Glasgow and Dr. Alfred
Bader for additional support.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1039/c2ob25472g|
|Appears in Collections:||Published Articles (Chemistry)|
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