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Title: Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives
Authors: Noole, Artur
Sucman, Natalia S.
Kabeshov, Mikhail A.
Kanger, Tonis
Macaev, Fliur Z.
Malkov, Andrei V.
Keywords: Catalysis
Asymmetric catalysis
Cascade reactions
Cyclization
Organocatalysis
Spiro compounds
Issue Date: 2012
Publisher: © Wiley-VCH
Citation: NOOLE, A. ... et al., 2012. Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives. Chemistry: a European Journal, 18 (47), pp. 14929-14933.
Abstract: Spirocyclopropanes: only one out of eight possible stereoisomers was obtained in the asymmetric cascade cyclopropanation of alkylidene oxindoles with ethyl 2-chloroacetoacetate. Improved catalyst design ensured that spirocyclopropyl oxindoles featuring two quaternary centers were synthesized in high yield and high enantio-and diastereoselectivity.
Description: This is the peer reviewed version of the following article: NOOLE, A. ... et al., 2012. Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives. Chemistry: a European Journal, 18 (47), pp. 14929-14933, which has been published in final form at: http://dx.doi.org/10.1002/chem.201203099.
Sponsor: We thank RSC for the International Joint Project grant JP090309 and TUT for travel fellowiship to AN. We acknowledge COST-ORCA action (CM0905) for creating networking and exchange opportunities.
Version: Accepted for publication
DOI: 10.1002/chem.201203099
URI: https://dspace.lboro.ac.uk/2134/15479
Publisher Link: http://dx.doi.org/10.1002/chem.201203099
ISSN: 0947-6539
Appears in Collections:Closed Access (Chemistry)

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