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|Title: ||Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans|
|Authors: ||Rakobowchuk, Mark|
Glover, Elisa I.
Phillips, Stuart M.
Tarnopolsky, Mark A.
MacDonald, Maureen J.
|Keywords: ||Blood flow|
|Issue Date: ||2011|
|Publisher: ||© Springer|
|Citation: ||RAKOBOWCHUK, M. ... et al, 2011. Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans. European Journal of Applied Physiology, 111 (2), pp.203-210.|
|Abstract: ||Short-term leg immobilization is an acute model of inactivity, which induces vascular
deconditioning. The present study was conducted to determine if short-term unilateral leg
immobilization induced alterations in central and peripheral conduit artery structure
(diameter and compliance),function (resting blood flow and mean wall shear rate) and
peripheral flow mediated dilation. Healthy participants (n=7 women and n=8 men) were
studied before and after 12 days of unilateral leg immobilization. Carotid artery structure
and function were unaltered with immobilization indicating that the unilateral
immobilization did not have a detectable effect on this representative central artery. In
contrast, peripheral measures of arterial structure at the common femoral and popliteal
arteries showed significant changes in both the immobilized and non-immobilized limbs
and the changes were greater in magnitude in the immobilized limb. Specifically,
femoral and popliteal artery compliance and femoral artery diameter were reduced in
both the immobilized and the non-immobilized limb (p<0.05) while popliteal artery
diameter was reduced only in the immobilized leg. Popliteal artery flow mediated
dilation, an indicator of peripheral artery function, was increased in the immobilized
limb, which parallels reports in paralyzed limbs of spinal cord injured individuals. The
time course of vascular alterations with inactivity likely follows a sequence of
adaptations in arterial structure and function reflecting differing initial flow patterns, and
arterial wall composition, and diverse hemodynamic stimuli within different blood
|Description: ||This paper is closed access.|
|Version: ||Closed access|
|Publisher Link: ||http://dx.doi.org/10.1007/s00421-010-1636-y|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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