Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/16292

Title: Flow-mediated dilation is acutely improved after high-intensity interval exercise
Authors: Currie, Katharine D.
McKelvie, Robert S.
MacDonald, Maureen J.
Keywords: Endothelium
Coronary Artery Disease
Issue Date: 2012
Publisher: Lippincott Williams & Wilkins (© American College of Sports Medicine)
Citation: CURRIE, K.D., MCKELVIE, R.S. and MACDONALD, M.J., 2012. Flow-mediated dilation is acutely improved after high-intensity interval exercise. Medicine and Science in Sports and Exercise, 44 (11), pp.2057-2064.
Abstract: Purpose: Cardiovascular disease is characterized by decreased endothelial function. Chronic exercise training improves endothelial function in individuals with cardiovascular diseases; however, the acute endothelial responses to a single bout of exercise are not consistent in the literature. This study investigated whether a single bout of moderate-intensity endurance exercise (END) and low-volume high-intensity interval exercise (HIT) on a cycle ergometer resulted in similar acute changes in endothelial function. Methods: Ten individuals (66 ± 11 yr) with coronary artery disease (CAD) participated in two exercise sessions (END and HIT). Endothelial-dependent function was assessed using brachial artery flow-mediated dilation (FMD) preexercise and 60 min postexercise. Brachial artery diameters and velocities were determined using Doppler ultrasound before and after a 5 min ischemic period at all time points. Endothelial-independent function was assessed using a 0.4-mg sublingual dose of nitroglycerin. Results: The total work performed was higher in END (166 ± 52 kJ) compared with HIT (93 ± 28 kJ) exercise (P < 0.001). Endothelial-dependent function improved (P = 0.01) after END (absolute FMD preexercise, 0.24 ± 0.18 mm; postexercise, 0.31 ± 0.24 mm) and HIT (absolute FMD preexercise, 0.25 ± 0.13 mm; postexercise, 0.29 ± 0.13 mm), with no differences between exercise conditions. A time effect for FMD normalized to the shear rate area under the curve was also observed (P = 0.02) after END (preexercise, 0.005 ± 0.004; postexercise, 0.010 ± 0.011) and HIT (preexercise, 0.005 ± 0.004; postexercise, 0.009 ± 0.011). Endothelial-independent function responses were unchanged after END and HIT (P > 0.05). Conclusions: HIT and END resulted in similar acute increases in brachial artery endothelial-dependent function in a population with dysfunction at rest, despite the difference in exercise intensities.
Description: This paper is closed access.
Sponsor: This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).
Version: Closed access
DOI: 10.1249/MSS.0b013e318260ff92
URI: https://dspace.lboro.ac.uk/2134/16292
Publisher Link: http://dx.doi.org/10.1249/MSS.0b013e318260ff92
ISSN: 0195-9131
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

Files associated with this item:

File Description SizeFormat
Acute FMD_MSSE FINAL ACCEPTED[1].pdfAccepted version270.58 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.