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Title: Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: a review
Authors: Han, Tao
Das, Diganta Bhusan
Keywords: Transdermal drug delivery
Sonophoresis
Microneedles
Iontophoresis
Chemical 29 enhancers
Permeability
Autoregressive integrated moving average
Cluster analysis
Issue Date: 2015
Publisher: © Elsevier
Citation: HAN, T. and DAS, D.B., 2015. Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: a review. European Journal of Pharmaceutics and Biopharmaceutics, 89, pp. 312-328.
Abstract: Transdermal drug delivery (TDD) is limited by the outer layer of the skin, i.e., the stratum corneum. Research on TDD has become very active in recent years and various technologies have been developed to overcome the resistance of the stratum corneum to molecular diffusion. In particular, researchers have started to consider the possibility of combining the TDD technologies in order to have further increase in drug permeability. Microneedles (MNs) and ultrasound are both promising technologies. They achieve enhancement in drug permeation via different mechanisms and therefore give a good potential for combining with each other. This review will focus on discussing the potential of this combinational technique along with other important issues, e.g., the mechanisms of ultrasound and MNs as it is these mechanisms which are coupled via the two systems (i.e. MNs and ultrasound). We discuss the possible ways to achieve this combination as well as how this combination would increase the permeability. Some of the undeveloped (weaker) research areas of MNs and sonophoresis are also discussed in order to understand the true potential of combining the two technologies when they are developed further in the future. We propose several hypothetical combinations based on the possible mechanisms involved in MNs and ultrasound. Furthermore, we carry out a cluster analysis by which we determine the significance of this combinational method in comparison with some other selected combinational methods for TDD (e.g., MNs and iontophoresis). Using a time series analysis tool (ARIMA model), the current trend and the future development of combined MNs and ultrasound are also analysed. Overall, the review in this paper indicates that combining MNs and ultrasound is a promising TDD method for the future.
Description: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version will be subsequently published in European Journal of Pharmaceutics and Biopharmaceutics .
Version: Accepted for publication
DOI: 10.1016/j.ejpb.2014.12.020
URI: https://dspace.lboro.ac.uk/2134/16498
Publisher Link: http://dx.doi.org/10.1016/j.ejpb.2014.12.020
ISSN: 0939-6411
Appears in Collections:Published Articles (Chemical Engineering)

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