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A new method of extraction of amoxicillin using mixed reverse micelles
journal contribution
posted on 2014-12-17, 15:08 authored by Sing C. Chuo, Siti H. Mohd-Setapar, Siti N. Mohamad-Aziz, Victor StarovA completely new method of extraction of amoxicillin using solubilisation by mixed reverse micelles was proposed and the optimal conditions for the process were found. Mixed AOT-TWEEN 85 reverse micelles were used for the first time as a new approach for extraction of amoxicillin. The effects of different process variables such as AOT-TWEEN 85 molar fractions, total surfactant concentration, pH of aqueous feed solution and potassium chloride concentration during forward extraction; stripping aqueous phase pH, potassium chloride (KCl) concentration and extraction time during backward extraction were investigated and the optimal conditions were found for all mentioned parameters. With the aid of response surface methodology, the optimum conditions for forward extraction are identified as (i) 5.5:1 molar ratio of AOT/TWEEN 85, (ii) total surfactant concentration 102.57. g/L, (ii) pH 1.90, and (vi) KCl concentration 8.54. g/L. The percentage of amoxicillin solubilised in isooctane was 95.54% under these optimal conditions. On the other hand, the optimum conditions for backward extraction are identified as (i) stripping aqueous phase pH 6.58, (ii) KCl concentration 11.02. g/L, and (iii) extraction time 15. min. Under these optimal conditions, the percentage of amoxicillin recovered was 90.79%. AOT/TWEEN 85 mixed surfactant system shows a significant advantage of saving the amount of surfactant for forward extraction. The addition of non-ionic surfactant helps to preserve natural function/activity of antibiotics as compared with a pure AOT surfactant used. The optimum conditions were also found for a backward recovery of amoxicillin.
Funding
Ministry of Science, Technology and Innovation (MOSTI) and Universiti Teknologi Malaysia (UTM)
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Colloids and Surfaces A: Physicochemical and Engineering AspectsVolume
460Pages
137 - 144Citation
CHUO, S.C. ... et al., 2014. A new method of extraction of amoxicillin using mixed reverse micelles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 460 pp. 137 - 144Publisher
© The Authors. Published by Elsevier B.V.Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/Publication date
2014Notes
This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/ISSN
0927-7757eISSN
1873-4359Publisher version
Language
- en