Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/16539

Title: Influence of array interspacing on the force required for successful microneedle skin penetration: theoretical and practical approaches
Authors: Olatunji, Ololade
Das, Diganta Bhusan
Garland, Martin J.
Belaid, Luc
Donnelly, Ryan F.
Keywords: Skin
Transdermal
Permeability
Absorption enhancer
Drug transport
Mathematical model
Microneedle
Microfabrication
Interspacing
Issue Date: 2013
Publisher: © Wiley Periodicals, Inc. and the American Pharmacists Association
Citation: OLATUNJI, O. ... et al, 2013. Influence of array interspacing on the force required for successful microneedle skin penetration: theoretical and practical approaches. Journal of Pharmaceutical Sciences, 102 (4), pp. 1209 - 1221.
Abstract: Insertion behaviour of microneedle (MN) arrays depends upon the mechanical properties of the skin and, MN geometry and distribution in an array. In addressing this issue, this paper studies MN array insertion mechanism into skin and provides a simple quantitative basis to relate the insertion force with distance between two MNs. The presented framework is based on drawing an analogy between a beam on an elastic foundation and mechanism of needle insertion, where insertion force is separated into different components. A theoretical analysis indicates that insertion force decreases as interspacing increases. For a specified skin type, insertion force decreased from 0.029 to 0.028N/MN when interspacing at MN tip was increased from 50μm (350μm at MN base) to 150μm (450μm at MN base). However, dependence of insertion force seems to decrease as the interspacing is increased beyond 150μm. To assess the validity of the proposed model, a series of experiments was carried out to determine the force required for skin insertion of MN. Experiments performed at insertion speed of 0.5 and 1.0mm/s yielded insertion force values of 0.030 and 0.0216N, respectively, for 30μm interspacing at MN base (330μm interspacing at tip) and 0.028 and 0.0214N, respectively, for 600μm interspacing at MN base (900μm interspacing at tip). Results from theoretical analysis and finite element modelling agree well with experimental results, which show MN interspacing only begins to affect insertion force at low interspacing (<150μm interspacing at MN base). This model provides a framework for optimising MN devices, and should aid development of suitable application method and determination of force for reliable insertion into skin. © 2013 Wiley Periodicals, Inc.
Description: This is the accepted version of the following article: OLATUNJI, O. ... et al, 2013. Influence of array interspacing on the force required for successful microneedle skin penetration: theoretical and practical approaches. Journal of Pharmaceutical Sciences, 102 (4), pp. 1209 - 1221, which has been published in final form at: http://dx.doi.org/10.1002/jps.23439
Version: Accepted for publication
DOI: 10.1002/jps.23439
URI: https://dspace.lboro.ac.uk/2134/16539
Publisher Link: http://dx.doi.org/10.1002/jps.23439
ISSN: 0022-3549
Appears in Collections:Published Articles (Chemical Engineering)

Files associated with this item:

File Description SizeFormat
Manuscript_JPS_3December_2012_CLEARED.pdfAccepted version502.48 kBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.