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Title: Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel
Authors: Nayak, Atul
Das, Diganta Bhusan
Vladisavljevic, Goran T.
Keywords: Gelatine
In vitro skin permeation
Sodium carboxymethylcellulose
Issue Date: 2014
Publisher: © Springer Science+Business Media
Citation: NAYAK, A., DAS, D.B. and VLADISAVLJEVIC, G.T., 2014. Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel. Pharmaceutical Research, 31 (5), pp. 1170 - 1184.
Abstract: Purpose Lidocaine hydrochloride (LidH) was formulated in sodium carboxymethyl cellulose/ gelatine (NaCMC/GEL) hydrogel and a ‘poke and patch’ microneedle delivery method was used to enhance permeation flux of LidH. Methods The microparticles were formed by electrostatic interactions between NaCMC and GEL macromolecules within a water/oil emulsion in paraffin oil and the covalent crosslinking was by glutaraldehyde. The GEL to NaCMC mass ratio was varied between 1.6 and 2.7. The LidH encapsulation yield was 1.2 to 7% w/w. LidH NaCMC/GEL was assessed for encapsulation efficiency, zeta potential, mean particle size and morphology. Subsequent in vitro skin permeation studies were performed via passive diffusion and microneedle assisted permeation of LidH NaCMC/GEL to determine the maximum permeation rate through full thickness skin. Results LidH 2.4% w/w NaCMC/GEL 1:1.6 and 1:2.3 respectively, possessed optimum zeta potential. LidH 2.4% w/ w NaCMC/GEL 1:2.3 and 1:2.7 demonstrate higher pseudoplastic behaviour. Encapsulation efficiency (14.9–17.2%) was similar for LidH 2.4% w/w NaCMC/GEL 1:1.6–1:2.3. Microneedle assisted permeation flux was optimum for LidH 2.4% w/w NaCMC/GEL 1:2.3 at 6.1 μg/ml/h. Conclusion LidH 2.4% w/w LidH NaCMC/GEL 1:2.3 crossed the minimum therapeutic drug threshold with microneedle skin permeation in less than 70 min.
Description: This article was published in the journal, Pharmaceutical Research [© Springer Science+Business Media] and the final publication is available at Springer via http://dx.doi.org/ 10.1007/s11095-013-1240-z
Version: Accepted for publication
DOI: 10.1007/s11095-013-1240-z
URI: https://dspace.lboro.ac.uk/2134/16628
Publisher Link: http://dx.doi.org/10.1007/s11095-013-1240-z
ISSN: 0724-8741
Appears in Collections:Published Articles (Chemical Engineering)

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