+44 (0)1509 263171
Please use this identifier to cite or link to this item:
|Title: ||Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel|
|Authors: ||Nayak, Atul|
Das, Diganta Bhusan
Vladisavljevic, Goran T.
In vitro skin permeation
|Issue Date: ||2014|
|Publisher: ||© Springer Science+Business Media|
|Citation: ||NAYAK, A., DAS, D.B. and VLADISAVLJEVIC, G.T., 2014. Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel. Pharmaceutical Research, 31 (5), pp. 1170 - 1184.|
|Abstract: ||Purpose Lidocaine hydrochloride (LidH) was formulated in
sodium carboxymethyl cellulose/ gelatine (NaCMC/GEL)
hydrogel and a ‘poke and patch’ microneedle delivery method
was used to enhance permeation flux of LidH.
Methods The microparticles were formed by electrostatic
interactions between NaCMC and GEL macromolecules within
a water/oil emulsion in paraffin oil and the covalent crosslinking
was by glutaraldehyde. The GEL to NaCMC mass ratio was
varied between 1.6 and 2.7. The LidH encapsulation yield was
1.2 to 7% w/w. LidH NaCMC/GEL was assessed for
encapsulation efficiency, zeta potential, mean particle size and
morphology. Subsequent in vitro skin permeation studies were
performed via passive diffusion and microneedle assisted
permeation of LidH NaCMC/GEL to determine the maximum
permeation rate through full thickness skin.
Results LidH 2.4% w/w NaCMC/GEL 1:1.6 and 1:2.3
respectively, possessed optimum zeta potential. LidH 2.4% w/
w NaCMC/GEL 1:2.3 and 1:2.7 demonstrate higher
pseudoplastic behaviour. Encapsulation efficiency (14.9–17.2%)
was similar for LidH 2.4% w/w NaCMC/GEL 1:1.6–1:2.3.
Microneedle assisted permeation flux was optimum for LidH
2.4% w/w NaCMC/GEL 1:2.3 at 6.1 μg/ml/h.
Conclusion LidH 2.4% w/w LidH NaCMC/GEL 1:2.3 crossed
the minimum therapeutic drug threshold with microneedle skin
permeation in less than 70 min.|
|Description: ||This article was published in the journal, Pharmaceutical Research [© Springer Science+Business Media] and the final publication is available at Springer via http://dx.doi.org/ 10.1007/s11095-013-1240-z|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1007/s11095-013-1240-z|
|Appears in Collections:||Published Articles (Chemical Engineering)|
Files associated with this item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.