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Title: Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry
Authors: Bag, Soumabha
Hendricks, P.I.
Reynolds, James C.
Cooks, R.G.
Keywords: Ambient mass spectrometry
Chemical derivatization
In-situ analysis
Mannich reaction
Reactive ionization
Trace analysis
Issue Date: 2015
Publisher: © Elsevier
Citation: BAG, S. ... et al, 2015. Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry. Analytica Chimica Acta, 860, pp.37–42.
Abstract: Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization. Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, n-dodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/. z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the aromatic aldehyde iminium ions fragment to give a characteristic product ion at m/. z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5. ng to 5. μg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2. ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.
Description: This is the author’s version of a work that was accepted for publication in Analytica Chimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published at: http://dx.doi.org/10.1016/j.aca.2015.01.007
Sponsor: The authors acknowledge funding from the National Science Foundation CHE1307264.
Version: Accepted for publication
DOI: 10.1016/j.aca.2015.01.007
URI: https://dspace.lboro.ac.uk/2134/16794
Publisher Link: http://dx.doi.org/10.1016/j.aca.2015.01.007
ISSN: 0003-2670
Appears in Collections:Published Articles (Chemistry)

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