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Title: The aging signature: a hallmark of induced pluripotent stem cells?
Authors: Rohani, Leili
Johnson, Adiv A.
Arnold, Antje
Stolzing, Alexandra
Keywords: Aging
Differentiation
Epigenetic
Induced pluripotent stem
Reprogramming
Telomeres
Issue Date: 2014
Publisher: The Anatomical Society and John Wiley and Sons Ltd / © The Authors
Citation: ROHANI, L. ... et al, 2014. The aging signature: a hallmark of induced pluripotent stem cells? Aging Cell, 13 (1), pp. 2 - 7.
Abstract: The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential. Furthermore, there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs. Although several groups have reported that reprogramming efficiency declines with age and is inhibited by genes upregulated with age, others have successfully generated iPSCs from senescent and centenarian cells. Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence. Defects such as these would hinder the clinical application of iPSCs, and as such, more comprehensive testing of iPSCs and their potential aging signature should be conducted. © 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Description: This is an open access article published by the Anatomical Society and John Wiley & Sons Ltd under a Creative Commons Attribution licence (CC-BY 3.0). Further details are available at: http://creativecommons.org/licenses/by/3.0/
Sponsor: The work presented in this paper was made possible by funding from the German Federal Ministry of Education and Research (BMBF 1315883).
Version: Published
DOI: 10.1111/acel.12182
URI: https://dspace.lboro.ac.uk/2134/16814
Publisher Link: http://dx.doi.org/10.1111/acel.12182
ISSN: 1474-9718
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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