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Title: Regulating aging in adult stem cells with microRNA
Authors: Hodzic, M.
Naaldijk, Yahaira
Stolzing, Alexandra
Keywords: Aging
Gene expression
MicroRNA
Senescence
Stem cells
Issue Date: 2013
Publisher: © Springer-Verlag Berlin Heidelberg
Citation: HODZIC, M., NAALDIJK, Y. and STOLZING, A., 2013. Regulating aging in adult stem cells with microRNA. Zeitschrift fur Gerontologie und Geriatrie, 46 (7), pp. 629 - 634.
Abstract: Aging can be defined as the result of accumulated cellular damage and deregulation of the epigenome. These changes cause impaired cell maintenance systems, reduced tissue regeneration, weakening of the immune system and increased risk of malignancy. The higher mortality rate in older individuals is a result of these pathologies. The study of age-related changes in adult stem cells and their regenerative potential is crucial to our understanding of the physical deterioration of organs and tissues. The growing interest and knowledge in the field of microRNAs adds a further dimension to this field of research. MicroRNAs are important posttranscriptional regulators of gene expression. They co-regulate stem cell properties such as potency, differentiation, self-renewal and senescence. Various cell systems, e.g. defense mechanisms against reactive oxygen radicals (ROS), DNA repair and apoptosis are regulated by microRNAs. These properties and the assumption that microRNAs act as some kind of general switch make them highly relevant in aging research.
Description: Closed access. The final publication is available at Springer via http://dx.doi.org/10.1007/s00391-013-0531-7
Sponsor: The work presented in this paper was made possible by funding from the German Federal Ministry of Education and Research (BMBF1315883).
Version: Published
DOI: 10.1007/s00391-013-0531-7
URI: https://dspace.lboro.ac.uk/2134/16818
Publisher Link: http://dx.doi.org/10.1007/s00391-013-0531-7
ISSN: 0948-6704
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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