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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/16833

Title: Cellular therapy using microglial cells
Authors: Schloendorn, John
Sethe, Sebastian
Stolzing, Alexandra
Issue Date: 2007
Publisher: © Mary Ann Liebert, Inc.
Citation: SCHLOENDORN, J., SETHE, S. and STOLZING, A., 2007. Cellular therapy using microglial cells. Rejuvenation Research, 10 (1), pp. 87 - 99.
Abstract: Recent insights into the function and dysfunction of microglia may inform future therapies to combat neurodegeneration. We hypothesise how different aspects of microglial activity including migration, activation, oxidative response, phagocytosis, proteolysis, and replenishment could be targeted by novel therapeutic approaches. A combined approach is suggested, encompassing opsonization and anti-inflamatory strategies in conjunction with an engineering of microglial precursors. Xenoproteases for bioremediation could be used to enhance intracellular and extracellular proteolytic capacity. The capacity of microglial precursors to cross the blood-brain barrier and to home in on sites of neural damage and inflammation might prove to be particularly useful for future therapeutic strategies. © Mary Ann Liebert, Inc.
Description: This article is closed access.
Version: Published
DOI: 10.1089/rej.2006.0511
URI: https://dspace.lboro.ac.uk/2134/16833
Publisher Link: http://dx.doi.org/10.1089/rej.2006.0511
ISSN: 1549-1684
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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