JONES, R.C.F. ... et al., 2015. Isoxazole to oxazole: a mild and unexpected transformation. Chemical Communications, 51 (6), pp. 1112 - 1115.
3-Aryltetrahydrobenzisoxazoles prepared en route to the coleophomone natural products and analogues, were found to undergo a remarkable base-mediated rearrangement to 2-aryltetrahydrobenzoxazoles. The scope of this unprecedented, facile transformation was probed: a range of analogues was produced, a mechanism proposed, and an application demonstrated by synthesis of a known herbicidal compound.
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