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| Title: | The au(I) catalyzed activation of allenamides and their subsequent transformation into chromanes: a method for the regiocontrolled addition to the alpha- and gamma-positions of the allene unit |
| Authors: | Slater, Natasha H.
Brown, Natalie J.
Elsegood, Mark R.J.
Kimber, Marc C. |
| Issue Date: | 2014 |
| Publisher: | © American Chemical Society |
| Citation: | SLATER, N.H. ... et al, 2014. The au(I) catalyzed activation of allenamides and their subsequent transformation into chromanes: a method for the regiocontrolled addition to the alpha- and gamma-positions of the allene unit. Organic Letters, 16 (17), pp.4606-4609. |
| Abstract: | Au(I) activation of allenamides in the presence of phenols leads to the formation of chromanes in moderate to good yields. This catalytic process is dependent on the counterion which facilitates the activation of the in situ formed imine. Furthermore, this iminium can be intercepted by trimethylallyl silane, via the Hosomi–Sakurai reaction, giving a formal procedure for the regioselective intermolecular addition of two carbon nucleophiles to an allenamide at the α- and γ-positions. |
| Description: | This definitive published version of this article is available from: http://dx.doi.org/10.1021/ol502178v |
| Version: | Accepted for publication |
| DOI: | 10.1021/ol502178v |
| URI: | https://dspace.lboro.ac.uk/2134/16851 |
| Publisher Link: | http://dx.doi.org/10.1021/ol502178v |
| ISSN: | 1523-7060 |
| Appears in Collections: | Published Articles (Chemistry)
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