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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/16869

Title: Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material
Authors: Stolzing, Alexandra
Widmer, Rebecca
Jung, Tobias
Voss, Peter
Grune, Tilman
Keywords: Aging
Oxidized proteins
Protein degradation
Vitamin E
Issue Date: 2006
Publisher: © Elsevier Inc.
Citation: STOLZING, A. ... et al., 2006. Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material. Free Radical Biology and Medicine, 40 (12), pp. 2126 - 2135.
Abstract: Proteins accumulate during aging and form insoluble protein aggregates. Microglia are responsible for their removal from the brain. During aging, changes within the microglia might play a crucial role in the malfunctioning of these cells. Therefore, we isolated primary microglial cells from adult rats and compared their activation status and their ability to degrade proteins to that of microglial cells isolated from newborn animals. The ability of adult microglial cells to degrade proteins is substantially decreased. However, the preincubation of microglial cells with vitamin E improves significantly the degradation of such modified proteins. The degradation of proteins from apoptotic vesicles is decreased in microglia isolated from adult rats. This might be the result of a suppression of the CD36 receptor due to vitamin E treatment. We concluded that microglial cells isolated from adult organisms have different metabolic properties and seem to be a more valuable model to study age-related diseases.
Description: Closed access
Sponsor: GK1033 and SFB575
Version: Published
DOI: 10.1016/j.freeradbiomed.2006.02.011
URI: https://dspace.lboro.ac.uk/2134/16869
Publisher Link: http://dx.doi.org/10.1016/j.freeradbiomed.2006.02.011
ISSN: 0891-5849
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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