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Title: Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
Authors: Mishto, Michele
Bellavista, Elena
Santoro, Aurelia
Stolzing, Alexandra
Ligorio, Claudia
Nacmias, Benedetta
Spazzafumo, Liana
Chiappelli, Martina
Licastro, Federico
Sorbi, Sandro
Pession, Annalisa
Ohm, Thomas
Grune, Tilman
Franceschi, Claudio
Keywords: Ageing
Alzheimer's disease
LMP2 polymorphism
Issue Date: 2006
Publisher: © Elsevier Inc
Citation: MISHTO, M. ... et al, 2006. Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiology of Aging, 27 (1), pp. 54 - 66.
Abstract: In this study, we investigated the presence and role of immunoproteasome and its LMP2 subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was present in brain areas such as hippocampus and cerebellum and localized in neurons, astrocytes and endothelial cells. A higher expression of immunoproteasome was found in brain of AD patients than in brain of non-demented elderly, being its expression in young brain negligible or absent. Furthermore, AD affected regions showed a partial decrease in proteasome trypsin-like activity. The study of LMP2 polymorphism (R/H) showed that it does not influence LMP2 expression (neither the mRNA nor mature protein) in brain tissue. However, control brain areas of AD patients carrying the RR genotype showed an increased proteasome activity in comparison with RH carriers. To test whether this effect of the genotype might be related to AD onset we performed a genetic study, which allowed us to exclude an association of LMP2 codon 60 polymorphism with AD onset, despite its influence on the proteasome activity in human brain. © 2005 Elsevier Inc. All rights reserved.
Description: This article is closed access.
Sponsor: This work was financed in part by a grant from project PROTAGE and FUNCTIONAGE, sponsored by the European Commission fifth Framework Program “Aging of the Population”
Version: Published
DOI: 10.1016/j.neurobiolaging.2004.12.004
URI: https://dspace.lboro.ac.uk/2134/16894
Publisher Link: http://dx.doi.org/10.1016/j.neurobiolaging.2004.12.004
ISSN: 0197-4580
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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