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Title: Microstructural and mechanical characteristics of PHEMA-based nanofibre-reinforced hydrogel under compression
Authors: Zhao, Weiwei
Shi, Zhijun
Chen, Xiuli
Yang, Guang
Lenardi, Cristina
Liu, Changqing
Keywords: 3-dimensional reinforcement
Mechanical properties
Finite element analysis (FEA)
Computational modelling
Issue Date: 2015
Publisher: © Elsevier
Citation: ZHAO, W. ... et al, 2015. Microstructural and mechanical characteristics of PHEMA-based nanofibre-reinforced hydrogel under compression. Composites Part B: Engineering, 76, pp.292–299.
Abstract: Natural network-structured hydrogels (e.g. bacterial cellulose (BC)) can be synthesised with specific artificial hydrogels (e.g. poly(2-hydroxyethyl methacrylate)(PHEMA)) to form a tougher and stronger nanofibre-reinforced composite hydrogel, which possesses micro- and nano-porous structure. These synthetic hydrogels exhibit a number of advantages for biomedical applications, such as good biocompatibility and better permeability for molecules to pass through. In this paper, the mechanical properties of this nanofibre-reinforced hydrogel containing BC and PHEMA have been characterised in terms of their tangent modulus and fracture stress/strain by uniaxial compressive testing. Numerical simulations based on Mooney-Rivlin hyperelastic theory are also conducted to understand the internal stress distribution and possible failure of the nanofibre-reinforced hydrogel under compression. By comparing the mechanical characteristics of BC, PHEMA, and PHEMA-based nanofibre reinforced hydrogel (BC-PHEMA) under the compression, it is possible to develop a suitable scaffold for tissue engineering on the basis of fundamental understanding of mechanical and fracture behaviours of nanofibre-reinforced hydrogels.
Sponsor: The authors would like to thank the 7th European Community Framework Program for financial support through a Marie Curie International Research Staff Exchange Scheme (IRSES) Project, entitled “Micro-Multi-Material Manufacture to Enable Multifunctional Miniaturized Devices (M6),”(Grant No. PIRSES-GA-2010-269113).
Version: Accepted for publication
DOI: 10.1016/j.compositesb.2015.02.033
URI: https://dspace.lboro.ac.uk/2134/16941
Publisher Link: http://dx.doi.org/10.1016/j.compositesb.2015.02.033
ISSN: 1359-8368
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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