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Title: Exercise in haemodialysis patients: impact on markers of inflammation
Authors: Dungey, Maurice
Keywords: Haemodialysis
End-stage renal disease
Exercise
Inflammation
Monocytes
Cardiovascular disease
Immune dysfunction
Regulatory T cells
Issue Date: 2015
Publisher: © Maurice Dungey
Abstract: End-stage renal disease patients have a greatly increased risk of cardiovascular disease partly attributed to the elevated levels of systemic inflammation observed in uraemia. One of the key mechanisms underlying inflammation appears to be the immune dysfunction that afflicts almost every aspect of the uraemic immune system. As a consequence patients experience immunosuppression and reduced responsiveness to antigen as well as a simultaneous over-activation leading to a pro-inflammatory environment. In addition, the haemodialysis (HD) treatment itself induces a proinflammatory response but may provide an otherwise opportune time to complete supervised exercise. [Continues.]
Description: A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.
URI: https://dspace.lboro.ac.uk/2134/17157
Appears in Collections:PhD Theses (Sport, Exercise and Health Sciences)

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