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Title: Salivary SIgA responses to acute moderate-vigorous exercise in monophasic oral contraceptive users
Authors: Hayashida, Harumi
Dolan, Nicola J.
Hounsome, Charlotte
Alajmi, Nawal
Bishop, Nicolette
Keywords: Oral contraceptive cycle
Upper respiratory symptoms
Aerobic exercise
Monophasic combined oral contraceptives
Issue Date: 2015
Publisher: NRC Research Press / © The Authors
Citation: HAYASHIDA, H. ... et al, 2015. Salivary SIgA responses to acute moderate-vigorous exercise in monophasic oral contraceptive users. Applied Physiology, Nutrition, and Metabolism, 40(9), pp.863-867.
Abstract: The purpose of this study was to examine the effect of oral contraceptive (OC) use on salivary secretory immunoglobulin A (SIgA) levels at rest and in response to an acute bout of moderate-vigorous exercise during two phases of the 4 week OC cycle corresponding to different phases of the synthetic menstrual cycle. Ten healthy active females completed a cycling at 70% V(・)O2peak for 45 min at two time points of an OC cycle: during the equivalent in time to the mid-follicular phase (day 8 ± 2) and the mid-luteal phase (day 20 ± 2). Timed unstimulated saliva samples were obtained before, immediately post exercise and 1 h post exercise and analyzed for salivary SIgA. Salivary SIgA secretion rate was 26 % (95% Confidence limits, CI, 6-46) lower at post-exercise compared with pre-exercise during the synthetic follicular phase (p = 0.019) but no differences were observed during the synthetic luteal trial. Saliva flow rate was 11% (95% CI, 8-30) lower at post-exercise compared with pre-exercise (main effect for time; p = 0.025). In conclusion, the pattern of salivary SIgA secretion rate response to moderate-vigorous exercise varies across the early and late phases of a monophasic OC cycle, with a transient reduction in salivary SIgA responses during the synthetic follicular phase. These findings indicate that monophasic OC use should be considered when assessing mucosal immune responses to acute exercise.
Description: This article was published in the journal Applied Physiology, Nutrition, and Metabolism. The definitive version is available from: http://www.nrcresearchpress.com/journal/apnm
Version: Accepted for publication
DOI: 10.1139/apnm-2014-0468
URI: https://dspace.lboro.ac.uk/2134/17202
Publisher Link: http://dx.doi.org/10.1139/apnm-2014-0468
ISSN: 1715-5320
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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