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Title: A new paradigm for numerical simulation of microneedle based drug delivery aided by histology of microneedle pierced skin
Authors: Han, Tao
Das, Diganta Bhusan
Keywords: Transdermal drug delivery
Microneedles
Numerical modeling and simulation
Histological image
Diffusion
Canny edge detection
Skin
Permeability
Absorption
Issue Date: 2015
Publisher: © Wiley Periodicals, Inc. and the American Pharmacists Association
Citation: HAN, T. and DAS, D.B., 2015. A new paradigm for numerical simulation of microneedle based drug delivery aided by histology of microneedle pierced skin. Journal of Pharmaceutical Sciences, 106 (6), pp.1993-2007.
Abstract: Microneedle (MN) is a relatively recent invention and an efficient technology for transdermal drug delivery (TDD). Conventionally, mathematical models of MNs drug delivery define the shape of the holes created by the MNs in the skin as the same as their actual geometry. Furthermore, the size of the MN holes in the skin is considered to be either the same or a certain fraction of the length of the MNs. However, the histological images of the MN-treated skin indicate that the real insertion depth is much shorter than the length of the MNs and the shapes may vary significantly from one case to another. In addressing these points, we propose a new approach for modeling MN-based drug delivery, which incorporates the histology of MN-pierced skin using a number of concepts borrowed from image processing tools. It is expected that the developed approach will provide better accuracy of the drug diffusion profile. A new computer program is developed to automatically obtain the outline of the MNs-treated holes and import these images into computer software for simulation of drug diffusion from MN systems. This method can provide a simple and fast way to test the quality of MNs design and modeling, as well as simulate experimental studies, for example, permeation experiments on MN-pierced skin using diffusion cell. The developed methodology is demonstrated using two-dimensional (2D) numerical modeling of flat MNs (2D). However, the methodology is general and can be implemented for three dimensional (3D) MNs if there is sufficient number of images for reconstructing a 3D image for numerical simulation. Numerical modeling for 3D geometry is demonstrated by using images of an ideal 3D MN. The methodology is not demonstrated for real 3D MNs, as there are not sufficient numbers of images for the purpose of this paper.
Description: This is the peer reviewed version of the article which has been published in final form at http://dx.doi.org/10.1002/jps.24425. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Version: Accepted for publication
DOI: 10.1002/jps.24425
URI: https://dspace.lboro.ac.uk/2134/17271
Publisher Link: http://dx.doi.org/10.1002/jps.24425
ISSN: 0022-3549
Appears in Collections:Published Articles (Chemical Engineering)

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