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Title: Sustained-release of naproxen sodium from electrospun-aligned PLLA/PCL scaffolds
Authors: Lui, Yuan Siang
Lewis, Mark P.
Loo, Say Chye Joachim
Keywords: Naproxen sodium
Adhesion formation
Tendon regeneration
Issue Date: 2017
Publisher: © John Wiley & Sons, Ltd.
Citation: LUI, Y.S., LEWIS, M.P. and LOO, S.C.J., 2017. Sustained-release of naproxen sodium from electrospun-aligned PLLA/PCL scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 11(4), pp. 1011-1021.
Abstract: Spontaneous tendon healing may result in reduced tissue functionality. In view of this, tissue engineering (TE) emerges as a promising approach in promoting proper tendon regeneration. However, unfavourable post-surgical adhesion formations restrict adequate tendon healing through the TE approach. Naproxen sodium (NPS), a non-steroidal anti-inflammatory drug (NSAID), has been demonstrated to prevent adhesions by inhibiting inflammatory response. Therefore, in this work, various factors, i.e. polymer composition (i.e. different poly-l-lactic acid (PLLA) to polycaprolactone (PCL) ratios) and percentage of water (H2O) to hexafluoroisopropanol (HFIP) as co-solvent, were investigated to understand how these can influence the release of NPS from electrospun scaffolds. By adjusting the amount of H2O as the co-solvent, NPS could be released sustainably for as long as two weeks. Scaffold breaking strength was also enhanced with the addition of H2O as the co-solvent. This NPS-loaded scaffold showed no significant cytotoxicity, and L929 murine fibroblasts cultured on the scaffolds were able to proliferate and align along the fiber orientation. These scaffolds with desirable tendon TE characteristics would be promising candidates in achieving better tendon regeneration in vivo.
Description: This is the peer reviewed version of the following article: LUI, Y.S., LEWIS, M.P. and LOO, S.C.J., 2015. Sustained-release of naproxen sodium from electrospun-aligned PLLA/PCL scaffolds. Journal of Tissue Engineering and Regenerative Medicine, which has been published in final form at http://dx.doi.org/10.1002/term.2000. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Version: Accepted for publication
DOI: 10.1002/term.2000
URI: https://dspace.lboro.ac.uk/2134/17339
Publisher Link: http://dx.doi.org/10.1002/term.2000
ISSN: 1932-6254
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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