BENYAHIA, B. ... et al, 2015. Optimized production of multilayered monodisperse polymer nanoparticles. Computer Aided Chemical Engineering, (37), pp.863-868.
A dynamic optimization frame work is used to produce in a controlled way multilayered
latex nanoparticles. The key feature of the method is to track a glass transition
temperature profile, which is designed to produce polymer layers with the targeted
properties. Several constraints are considered to achieve better control and produce
nanoparticles with a specified particle diameter and layers’ thicknesses. To enhance the
control of the different layers, two separate monomer feeds are considered under
starving conditions throughout the fed-batch stages. The emulsion copolymerization of
styrene and butyl acrylate in the presence of n-C12 mercaptan, as chain transfer agent
(CTA), is illustrated here as a case study. The optimal feed profiles of the preemulsioned
monomers are obtained using a genetic algorithm.