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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/17574

Title: Photo-polymerisable electrospun fibres of N-methacrylate glycol chitosan for biomedical applications
Authors: Romano, Ilaria
Mele, Elisa
Heredia-Guerrero, Jose A.
Ceseracciu, Luca
Hajiali, Hadi
Goldoni, Luca
Marini, Lara
Athanassiou, Athanassia
Keywords: Regenerative medicine
Composite scaffold
Stem-cells
Nanofibers
Tissue
Morphology
Behavior
Mats
Issue Date: 2015
Publisher: © Royal Society of Chemistry
Citation: ROMANO, I. ... et al., 2015. Photo-polymerisable electrospun fibres of N-methacrylate glycol chitosan for biomedical applications. RSC Advances, 5 (31), pp. 24723 - 24728.
Abstract: The availability of nanofibrous substrates with engineered properties, such as controlled porosity, mechanical conformability, biodegradation profile and drug release, is of strategic importance in the biomedical sector. Here, we demonstrate that N-methacrylate glycol chitosan, a photo-polymerisable, biocompatible and water-soluble derivative of chitosan, can be easily processed to create non-woven mats of nanofibres with controlled physicochemical characteristics. The produced fibrous mats are characterised by thermal stability, Young's modulus of 140 MPa and ultimate strength of 4 MPa. The degree of cross-linking of the realised fibres regulates their durability and degradation profile under conditions of high humidity, but also allows controlling the delivery over time of active agents encapsulated inside the fibres. We demonstrate that the N-methacrylate glycol chitosan nanofibres are able to release an antimicrobial drug within 24 hours. Moreover, cells proliferation of 85% indicates that non-cytotoxic substances were released from the electrospun mats.
Description: This article was published in the journal RSC Advances [© Royal Society of Chemistry] and the definitive version is available at: http://dx.doi.org/10.1039/c5ra02301g
Sponsor: Jose A. Heredia-Guerrero is supported by a Marie Curie IntraEuropean Fellowship (BIOPROTO project), financed by the EU's Seventh Framework Programme for Research (FP7).
Version: Accepted for publication
DOI: 10.1039/c5ra02301g
URI: https://dspace.lboro.ac.uk/2134/17574
Publisher Link: http://dx.doi.org/10.1039/c5ra02301g
ISSN: 2046-2069
Appears in Collections:Published Articles (Materials)

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