Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/17575

Title: Alginate nanofibrous mats with adjustable degradation rate for regenerative medicine
Authors: Hajiali, Hadi
Heredia-Guerrero, Jose A.
Liakos, Ioannis
Athanassiou, Athanassia
Mele, Elisa
Keywords: Sodium alginate
Issue Date: 2015
Publisher: © American Chemical Society
Citation: HAJIALI, H. ... et al., 2015. Alginate nanofibrous mats with adjustable degradation rate for regenerative medicine. Biomacromolecules, 16 (3), pp. 936 - 943.
Abstract: The broad utilization of electrospun scaffolds of sodium alginate in tissue engineering is strongly limited by their high solubility in aqueous environments and by the difficulty to adjust their degradation dynamics. Here, an alternative strategy to enhance the stability and to control the degradability of alginate nanofibers is described by treating them with trifluoroacetic acid for specific time intervals. It is demonstrated that, by increasing the duration of the acid treatment procedure, a lower degradation rate of the resulting fibers in buffer solutions can be achieved. Furthermore, the produced mats are free from cytotoxic compounds and are highly biocompatible. The properties conferred to the alginate nanofibrous mats by the proposed method are extremely attractive in the production of innovative biomedical devices.
Description: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/bm501834m
Sponsor: Silvia Dante is acknowledged for providing the NIH/3T3 cells. J.A.H.-G. acknowledges the BIOPROTO project (Marie Curie Intra-European Fellowship), financed by the EU Seventh Framework Program for Research (FP7).
Version: Accepted for publication
DOI: 10.1021/bm501834m
URI: https://dspace.lboro.ac.uk/2134/17575
Publisher Link: http://dx.doi.org/10.1021/bm501834m
ISSN: 1525-7797
Appears in Collections:Published Articles (Materials)

Files associated with this item:

File Description SizeFormat
Manuscript_Biomacrom.pdfAccepted version748.55 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.