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|Title: ||Alginate nanofibrous mats with adjustable degradation rate for regenerative medicine|
|Authors: ||Hajiali, Hadi|
Heredia-Guerrero, Jose A.
|Keywords: ||Sodium alginate|
|Issue Date: ||2015|
|Publisher: ||© American Chemical Society|
|Citation: ||HAJIALI, H. ... et al., 2015. Alginate nanofibrous mats with adjustable degradation rate for regenerative medicine. Biomacromolecules, 16 (3), pp. 936 - 943.|
|Abstract: ||The broad utilization of electrospun scaffolds of sodium alginate in tissue engineering is strongly limited by their high solubility in aqueous environments and by the difficulty to adjust their degradation dynamics. Here, an alternative strategy to enhance the stability and to control the degradability of alginate nanofibers is described by treating them with trifluoroacetic acid for specific time intervals. It is demonstrated that, by increasing the duration of the acid treatment procedure, a lower degradation rate of the resulting fibers in buffer solutions can be achieved. Furthermore, the produced mats are free from cytotoxic compounds and are highly biocompatible. The properties conferred to the alginate nanofibrous mats by the proposed method are extremely attractive in the production of innovative biomedical devices.|
|Description: ||This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see http://dx.doi.org/10.1021/bm501834m|
|Sponsor: ||Silvia Dante is acknowledged for providing the NIH/3T3 cells.
J.A.H.-G. acknowledges the BIOPROTO project (Marie Curie
Intra-European Fellowship), financed by the EU Seventh
Framework Program for Research (FP7).|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1021/bm501834m|
|Appears in Collections:||Published Articles (Materials)|
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