JONES, R.C.F. ... et al, 2014. New routes towards reutericyclin analogues. Chemical Communications, 50 (13), pp.1588-1590
A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-5 acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for their antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.
This paper was submitted for publication in the journal Chemical Communications. The definitive version can be found at: http://dx.doi.org/10.1039/c3cc47867j