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|Title: ||Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles|
|Authors: ||Stevens, Deborah|
Grimshaw, Sally G.
Arnold, David S.
Fernstad, Sara J.
Smith, Adrian M.
Heaney, Liam M.
Reynolds, James C.
Thomas, C.L. Paul
|Keywords: ||Isovaleric acid|
|Issue Date: ||2015|
|Publisher: ||Oxford University Press © FEMS|
|Citation: ||STEVENS, D. et al., 2015. Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles. FEMS Microbiology Ecology, 91 (1), pp. 1-11.|
|Abstract: ||The human foot provides an ideal environment for the colonization and growth of bacteria and subsequently is a body site
associated with the liberation of odour. This study aimed to enumerate and spatially map bacterial populations’ resident
across the foot to understand any association with odour production. Culture-based analysis confirmed that Staphylococci
were present in higher numbers than aerobic corynebacteria and Gram-positive aerobic cocci, with all species being present
at much higher levels on the plantar sites compared to dorsal sites. Microbiomic analysis supported these findings
demonstrating that Staphylococcus spp. were dominant across different foot sites and comprised almost the entire bacterial
population on the plantar surface. The levels of volatile fatty acids, including the key foot odour compound isovaleric acid,
that contribute to foot odour were significantly increased at the plantar skin site compared to the dorsal surface. The fact
that isovaleric acid was not detected on the dorsal surface but was present on the plantar surface is probably attributable to
the high numbers of Staphylococcus spp. residing at this site. Variations in the spatial distribution of these microbes appear
to be responsible for the localized production of odour across the foot.|
|Description: ||This is a pre-copyedited, author-produced PDF of an article accepted for publication in FEMS Microbiology Ecology following peer review. The version of record STEVENS, D. et al., 2015. Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles. FEMS Microbiology Ecology, 91 (1), pp. 1-11 is available online at: http://dx.doi.org/10.1093/femsec/fiu018|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1093/femsec/fiu018|
|Appears in Collections:||Published Articles (Chemistry)|
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