File(s) under permanent embargo
Reason: This item is currently closed access.
Through-wall mass transport as a modality for safe generation of singlet oxygen in continuous flows
journal contribution
posted on 2015-08-04, 11:12 authored by Katherine S Elvira, Robert C.R. Wootton, Nuno Reis, Malcolm R. Mackley, Andrew J. DeMelloSinglet oxygen, a reactive oxygen species, has been a basic synthetic tool in the laboratory for many years. It can be generated either through a chemical process or most commonly via a photochemical process mediated by a sensitizing dye. The relative paucity of singlet oxygen employment in fine chemical industrial settings can be attributed to many factors, not least the requirement for excessive quantities of oxygenated organic solvents and the dangers that these represent. Microcapillary films (MCFs) are comprised of multiple parallel channels embedded in a plastic film. In this study, MCFs are employed as flow reactor systems for the singlet oxygen mediated synthesis of ascaridole. No gaseous oxygen is supplied directly to the reaction, rather mass transport occurs exclusively through the reactor walls. The rate of production of ascaridole was found to be strongly dependent on the partial pressure of oxygen present within the reaction system. This methodology significantly simplifies reactor design, allows for increased safety of operation, and provides for space-time yields over 20 times larger than the corresponding bulk synthesis. © 2013 American Chemical Society.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
ACS Sustainable Chemistry and EngineeringVolume
1Issue
2Pages
209 - 213Citation
ELVIRA, K.S. ... et al, 2013. Through-wall mass transport as a modality for safe generation of singlet oxygen in continuous flows. ACS Sustainable Chemistry and Engineering, 1 (2), pp.209-213Publisher
© American Chemical SocietyVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2013Notes
This paper is closed access.eISSN
2168-0485Publisher version
Language
- en