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|Title: ||Through-wall mass transport as a modality for safe generation of singlet oxygen in continuous flows|
|Authors: ||Elvira, Katherine S|
Wootton, Robert C.R.
Reis, Nuno M.
Mackley, Malcolm R.
DeMello, Andrew J.
|Issue Date: ||2013|
|Publisher: ||© American Chemical Society|
|Citation: ||ELVIRA, K.S. ... et al, 2013. Through-wall mass transport as a modality for safe generation of singlet oxygen in continuous flows. ACS Sustainable Chemistry and Engineering, 1 (2), pp.209-213|
|Abstract: ||Singlet oxygen, a reactive oxygen species, has been a basic synthetic tool in the laboratory for many years. It can be generated either through a chemical process or most commonly via a photochemical process mediated by a sensitizing dye. The relative paucity of singlet oxygen employment in fine chemical industrial settings can be attributed to many factors, not least the requirement for excessive quantities of oxygenated organic solvents and the dangers that these represent. Microcapillary films (MCFs) are comprised of multiple parallel channels embedded in a plastic film. In this study, MCFs are employed as flow reactor systems for the singlet oxygen mediated synthesis of ascaridole. No gaseous oxygen is supplied directly to the reaction, rather mass transport occurs exclusively through the reactor walls. The rate of production of ascaridole was found to be strongly dependent on the partial pressure of oxygen present within the reaction system. This methodology significantly simplifies reactor design, allows for increased safety of operation, and provides for space-time yields over 20 times larger than the corresponding bulk synthesis. © 2013 American Chemical Society.|
|Description: ||This paper is closed access.|
|Publisher Link: ||http://dx.doi.org/10.1021/sc300093j|
|Appears in Collections:||Closed Access (Chemical Engineering)|
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